XPoRting (poly)phosphates limits thrombosis
نویسندگان
چکیده
منابع مشابه
Diphosphoinositol polyphosphates: metabolic messengers?
The diphosphoinositol polyphosphates ("inositol pyrophosphates") are a specialized subgroup of the inositol phosphate signaling family. This review proposes that many of the current data concerning the metabolic turnover and biological effects of the diphosphoinositol polyphosphates are linked by a common theme: these polyphosphates act as metabolic messengers. This review will also discuss the...
متن کاملSelective splitting of 3'-adenylated dinucleoside polyphosphates by specific enzymes degrading dinucleoside polyphosphates.
Several 3'-[(32)P]adenylated dinucleoside polyphosphates (Np(n)N'p*As) were synthesized by the use of poly(A) polymerase (Sillero MAG et al., 2001, Eur J Biochem.; 268: 3605-11) and three of them, ApppA[(32)P]A or ApppAp*A, AppppAp*A and GppppGp*A, were tested as potential substrates of different dinucleoside polyphosphate degrading enzymes. Human (asymmetrical) dinucleoside tetraphosphatase (E...
متن کاملControl of Vertebrate Skeletal Mineralization by Polyphosphates
BACKGROUND Skeletons are formed in a wide variety of shapes, sizes, and compositions of organic and mineral components. Many invertebrate skeletons are constructed from carbonate or silicate minerals, whereas vertebrate skeletons are instead composed of a calcium phosphate mineral known as apatite. No one yet knows why the dynamic vertebrate skeleton, which is continually rebuilt, repaired, and...
متن کاملCorrection: The new world of inorganic polyphosphates.
Figure 1 Model of two independent PTMs, serine-pyrophosphorylation and lysine-polyphosphorylation Protein pyrophosphorylation is the transfer of the b-phosphate group of the pyrophosphate moiety of IP7 on to a pre-phosphorylated serine residue (left) [16,17]. Conversely, protein polyphosphorylation is the covalent attachment of a chain of inorganic polyP on to a lysine residue dependent on the ...
متن کاملRegulation of chromatin remodeling by inositol polyphosphates.
Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine tripho...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2020008973